Natural compounds, which have evolved their function over millions of years, are often more efficient than man–made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell.This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes.Key features:Covers the synthesis, semi–synthesis and also biosynthesis of potentially bioactive natural productsFeatures chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure–activity relationships40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biologyForward–looking: Addresses opportunities and cutting–edge developments rather than well–documented basic knowledge, pinpoints current trends and future directions in this rapidly–evolving fieldApplication–oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnologyThis book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries. INDICE: Bioactive natural compound target validation through global genomic approaches.High–throughput drug screening based on cancer signalling and its application in natural product screening.Activators and inhibitors od ADAM–10 for management of cancer and Alzheimer?s Disease.From marine organism to potential drug: Using innovative techniques for identifying novel compounds and modes of action.Marine natural products: biodiversity, biodiscovery and bioproduction.Naturally occurring antioxidants against oxidative stress–mediated organ dysfunctions.Structure and biological activity of the polyether ionophores and their semi–synthetic derivatives.The potential of depsipeptides from terrestrial and marine microorganisms in the fight against human protozoan disease.Biosynthesis of phenylpropanoids and their biological activities.Sequiterpene lactones and their semi–synthetic analogs as potential anticancer agents.Synthesis and pharmacology of flavaglines.Isoquinoline alkaloids and their analogs: nucleic acid and protein binding aspects and therapeutic potential.Neuropeptides: active neuromodulators in the pathophysiology of major affective disorders and suicidal behavior.Quantitative structure–toxicity relationship studies on natural insecticide pyrethrin and its analogs.Summary and outlook..(partial contents)
- ISBN: 978-3-527-33794-1
- Editorial: Wiley VCH
- Encuadernacion: Rústica
- Páginas: 544
- Fecha Publicación: 11/02/2015
- Nº Volúmenes: 1
- Idioma: Inglés