Cancer vaccines: challenges and opportunities in translation

Recent advances in immunology and biology have opened new horizons in cancer therapy, Included in the expanding array of cancer treatment options are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. CancerVaccines Challenges and Opportunities in Translaton is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. INDICE: Cancer biology: Meeting the challenge of variability via personalized immunotherapies. Outlining the gap between preclinical models and clinicalsituation. Theranostic’ approaches as a strategy to tackle the variability inclinic. State of the art in active immunotherapies. Cell based approaches. Dendritic cell based immunization. Cancer vaccines based on allogeneic cell lines. Personalized cancer vaccines. Antigen based approaches. Peptide based active immunotherapy in cancer. Microbial vector approaches. Prime – boost strategies to immunize against cancer antigens. Biomarker guided R&D and clinical development. Predicting responsiveness (theranostic approaches.Predicting clinicalresponse and evolution . Predicting toxicities.Bringing new therapeutics to and through development: Translational medicine in support of active immunotherapies in cancer. Flexible trial design and bi-directional bedside-lab bench processes as a means to expedite the development of immunotherapies. Combinatorial approaches as a means to improve on efficacy of cancer vaccines.

• ISBN: 978-1-4200-5467-5
• Editorial: INFORMA HEALTHCARE BOOKS
• Encuadernacion: Cartoné
• Páginas: 224
• Fecha Publicación: 01/04/2008
• Nº Volúmenes: 1
• Idioma: Inglés