This book provides an in-depth account of all aspects of radioembolization, arelatively novel technique based on the efficacy of radiotherapy for the treatment of liver tumors. Radioembolization combines embolization (intravascular deployment of particles - microspheres loaded with yttrium-90) and brachytherapy (local administration of radiotherapy), thereby allowing delivery of high doses of beta-radiation specifically to the tumoral area in an attempt to overcome the problem of permanent radiation-induced damage to nontumoral liver parenchyma. Performance of the procedure demands close familiarity with the hepatic vascular anatomy in order to ensure avoidance of vessels going to other territories. Furthermore, a detailed knowledge of liver function, tumor volume, and liver vascular shunting is needed in order to calculate the appropriate therapeutic dose in each particular case. All of these topics are addressed in depth in this book, and initial promising clinical results are presented. Provides an in-depth account of all aspects of liver radioembolization, a relatively novel technique that allows delivery of high doses of beta-radiation specifically to the tumoral area. Includes detailed relevant information on candidate selection, vascular anatomy, dosimetry and treatment evaluation. Presents initial promising clinical results and potential side-effects. Examines future directions INDICE: 90Y Microspheres: Concepts and Principles. Identification of Candidates and Selection Criteria. Radiologic Evaluation of Patients with Liver Tumours. Vascular Anatomy and Angiographic Techniques. Identifying and Managing Anatomical Variants. Dosimetry and Dose Calculation. Improving Treatment Designby Image Fusion Techniques. Nuclear Medicine Procedures for Treatment Evaluation. Radiologic Assesment of Tumour Response. Results in Hepatocellular Carcinoma. Results in Liver Metastatic Colorectal Cancer. Results in Other Liver Metastases. Results in Liver Metastases from Neuroendocrine Tumours. Complications and Side-Effects . Future Directions in Radioembolization. Subject Index. List of Contributors.
- ISBN: 978-3-540-35421-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 190
- Fecha Publicación: 01/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés