Systems Chemical Biology: Integrating Chemistry and Biology Through Cheminformatics Approaches

This book will provide a descriptive outline of both thefundamental and the applied aspects of systems chemical biologyapproaches, focused primarily on the drug discovery context. Itwill cover a broad range of aspects related to prediction ofphenotypic outcome to interfering with key pathways, as well as thedesign of small molecule modulators aimed at causing a desiredphenotype (or to reverse a given diseased phenotype). These relateto both cellular pathways with the goals of understanding andpredicting function, and to strategies in multi–drug targeting.This can also be gauged from the rapid growth in the literature inthis direction and the creation of new computational/bioinformaticsjournals.  The book will also provide an overview, witheasy–to–understand chapters written by pioneers and leaders inthe field, as well as advanced material, to inform the readers ofthe potential caveats which might be involved in a particular taskat hand.  It also clearly highlight the scope of SystemsChemical Biology and includes case studies where computationalnetwork models have provided experimental insight.

• ISBN: 978-0-470-55447-0
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 06/05/2015
• Nº Volúmenes: 1
• Idioma: Inglés