Susceptibility to infectious diseases: the importance of host genetics

In the last fifteen years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has accumulated that host genes are important determinants of the outcome of infection for many common pathogens. This book summarises advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance such as malaria and HIV, and those of topical interest such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made and the book is therefore useful to anyone planning genetic studies on a multi-factorial disease, regardless of whether it has an infectious etiology. INDICE: 1. Introduction Richard Bellamy; 2. Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections Alexandre Alcais and Laurent Abel; 3. The diverse genetic basis of immunodeficiencies Mauno Vihinen; 4. Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases Leland J. Yee and Mark R. Thursz; 5. The cystic fibrosis transmembrane conductance regulator Alan W. Cuthbert; 6. The influence of inherited traits on malaria infection David J. Roberts, Tyler Harris and Thomas Williams; 7. Polymorphic chemokine receptor and ligand genes in HIV infection Jianming (James) Tang and Richard A. Kaslow; 8. N-ramp and resistance in intracellular pathogens Philippe Gros and Erwin Schurr; 9. The interleukin-12-interferon-y loop is required for protective immunity to experimental and natural infections by mycobacterium Marion Bonnet, Claire Soudais and Jean-Laurent Casanova; 10. Mannose-binding lectin deficiency and susceptibility to infectious disease Dominic L. Jack, Nigel J. Klein and Malcolm W. Turner; 11. Blood group phenotypes and infectious diseases C. Caroline Blackwell, Donald M. Weir, Abdulhamid M. Alkout, Omar R. El Ahmer, Doris A. C. Mackenzie, Valerie S. James, J. Matthias Braun, Osama M. Almadani and Anthony Busuttil; 12. Genetics of human susceptibility to infection and hepatic disease caused by schistosomes AlainJ. Dessein, Nasureldin El Wali, Sandrine Marquet, Laurent Abel, Virmondes Rodrigues Jr., Carole Eboumbou Moukoko, Helia Dessein, Laurent Argiro, Sandrine Henri, Dominique Hillaire, Gachuhi Kimani, Aluizio Prata, Mubarak Magzoub and Christophe Chevillard; 13. Genetic susceptibility to prion diseases Matthew Bishop and J. W. Ironside.

• ISBN: 978-0-521-12959-6
• Editorial: Cambridge University
• Encuadernacion: Rústica
• Páginas: 424
• Fecha Publicación: 04/02/2010
• Nº Volúmenes: 1
• Idioma: Inglés