Medicinal Chemistry: Fundaments presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia - the industrialist's bible - its role, and a description of the monographs of active principles. Defines the lifecycle of drugsExplains the physico-chemical properties and consequences of a drugStudies the fundamental concepts of medicinal chemistryDescribes the active ingredient monographs INDICE: 1. Medicines and Drugs 2. Importance and Evaluation of the pKa 3. Importance and Evaluation of Lipophilicity 4. Importance and Evaluation of Solubility 5. Importance and Evaluation of the Polar Surface Area (PSA and TPSA) 6. Lipinski's Rule of Five 7. Principle of a Prodrug 8. Pharmacophore 9. The European Pharmacopoeia
- ISBN: 978-1-78548-288-5
- Editorial: ISTE Press - Elsevier
- Encuadernacion: Cartoné
- Páginas: 172
- Fecha Publicación: 03/07/2018
- Nº Volúmenes: 1
- Idioma: Inglés