Cancer microenvironment and therapeutic implications: tumor pathophysiology mechanisms and therapeutic strategies

In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and hostinteractions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at thelaboratory bench and in the clinic. These physician-scientists have dedicatedthemselves to the tension between the urgency for cures and the technical challenges of discovery. A bird’s-eye view of cancer biology A critical appraisalof cancer’s context in addition to its substance Written by a team of physician-scientists merging experiences at the lab bench with the fight in the cancer clinic INDICE: From the contents Part 1. Tumor Physiopathology and Microenvironment Genesis. 1. Inflammation and carcinogenesis: a change in the metabolic process. 2. Tumour microenvironment. Aspects of stromal-parenchymal interaction. 3. Significance of tumor microenvironment on the genesis of : Interstitial Fluid, angiogenesis Hemostatic / Hemorheologic Abnormalities. Pathogenesis and therapeutic aspects. 4. Cancer Stem Cells in the Neoplastic Niche. Part 2. Tumor Microenvironment, Therapeutic Perspectives and Strategies for Normalization. 5. Barriers to drug Delivery in cancer. Clinical implications. 6. Hypoxia, hyperthermia, chemotherapy: interactions and opportunities. 7. Effects of molecularly targeting hypoxia in oncology: part A) Theory- RCC as a model; part B) example of method for reducing side induced acute hypoxia by TACE for treating liver. 8. Significance of tumour microenvironment on Radiotherapy. 9. Effects oftumor microenvironment on Immunity. Clinical considerations.

• ISBN: 978-1-4020-9575-7
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 335
• Fecha Publicación: 01/03/2009
• Nº Volúmenes: 1
• Idioma: Inglés