With its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable “simple” species such as Drosophila melanogoster (fruit flies), Caenorhabdtis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods™ series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field. Provides an easily accessible reference for emerging animal models of epilepsy written by leading researchers in the field Details the latest innovations and methodologies currently being applied in the field of epilepsy research Covers a wide range of species andapproaches Moves beyond traditional animal models to encompass organisms and strategies that are at the cutting-edge of neuroscience INDICE: The Nematode, C. elegans, as an Emerging Model for Investigating Epilepsy.- The Genetics and Molecular Biology of Seizure Susceptibility in Drosophila.- The Albino Xenopus laevis Tadpole as a Novel Model of Developmental Seizures.- Zebrafish as a Simple Vertebrate Organism for Epilepsy Research.- Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability.- BK Potassium Channels Mutations Affecting Neuronal Function and Epilepsy.- Mouse Models of Benign Familial Neonatal Convulsions (BFNC): Mutations in KCNQ (Kv7) Genes.- Interneuron Loss as a Cause of Seizures: Lessons from Interneuron-Deficient Mice.- Imaging Seizure Propagation In Vitro.- Complexity Untangled: Large-Scale Realistic Computational Models in Epilepsy.- Organotypic Hippocampal Slice Cultures as a Model of Limbic Epileptogenesis.- Seizure Analysis and Detection In Vivo.- Viral Vector Gene Therapy for Epilepsy.- Neural Stem Cells in Experimental Mesial Temporal Lobe Epilepsy.
- ISBN: 978-1-60327-262-9
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 270
- Fecha Publicación: 01/05/2009
- Nº Volúmenes: 1
- Idioma: Inglés