Regulation of gene expression in the tumor environment: regulation of melanoma progression by the microenvironment : the roles of PAR-1 and PAFR

It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interactionbetween the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. Describes the contribution of the tumor microenvironment to tumor growth and metastasis Gives a unique opportunity to understand the cross talk between tumor cells (the seed) and the organ microenvironment (the soil) Discusses therapy targeting the microenvironment rather than the tumor cells INDICE: 1, Regulation of Melanoma Progression by the Tumor Microenvironment: the Roles of PAR-1 and PAFR.- 2, Functions of Autocrine Motility Factor at the Tumor Microenvironment.- 3, Targeting Signaling Pathways - in the search of Melanoma's Achilles' heel.- 4, Regulation of Gene Expression in Tumor and Non-Tumor Cells in the Tumor Microenvironment. Impact of ErbB2 Over-Expression on Tumor and Tumor Microenvironment that facilitate tumor progression and metastasis.- 5, Intercellular and Cytoskeletal Signaling Converge at PAK's.- 6, Molecular Basis for Vascular Endothelial Growth Factor Expression Tumor.- 7, Incipent Event in Human carcinogenesis: A Concept of Forerunner Genes.

• ISBN: 978-1-4020-8340-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 250
• Fecha Publicación: 01/06/2008
• Nº Volúmenes: 1
• Idioma: Inglés