This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease. Overview of some of the key concepts in epigenetics, chromatin and the interaction with transcription factors. Shows the specific influence of environmental factors to influence or trigger the autoimmune response. Discusses the possibilities of using epigenetics-based therapies in the context of autoimmune diseases. Presents the application of novel methods to characterize the epigenetic profile. INDICE: AN INTRODUCTION TO EPIGENETICS. CHROMATIN MECHANISMS REGULATING GENE EXPRESSION IN HEALTH AND DISEASE. EPIGENETIC CONTROL OF LYMPHOCYTE DIFERENTIATION. EPIGENETIC CONTROL IN IMMUNE FUNCTION. DNA METHYLATION AND B?CELL AUTOR EACTIVITY. ENVIRONMENTAL AGENTS AND AUTOIMMUNE DISEASES. EPIGENETIC DYSREGULATION OF EPSTEIN?BARR VIRUS LATENCY AND DEVELOPMENT OF AUTOIMMUNE DISEASE. DOES GENOMIC IMPRINTING PLAY A ROLE INáAUTOIMMUNITY?. A NEW EPIGENETIC CHALLENGE:SYSTEMIC LUPUS ERYTHEMATOSUS. EPIGENETIC DEREGULATION INáRHEUMATOID ARTHRITIS. PROSPECTS FOR EPIGENETIC COMPOUNDS INáTHE TREATMENT OF AUTOIMMUNE DISEASE. PROFILING EPIGENETIC ALTERATIONSáINáDISEASE.
- ISBN: 978-1-4419-8215-5
- Editorial: Springer US
- Encuadernacion: Cartoné
- Páginas: 178
- Fecha Publicación: 27/02/2011
- Nº Volúmenes: 1
- Idioma: Inglés