Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies

Disease-Modifying Therapies and Targets in Neurodegenerative Disorders examines specific neurodegenerative disorders chapter-by-chapter, each written by experts in the respective fields. Each chapter contains a summary of the disease management field as it stands today and subsequently elaborates on the molecular mechanisms and new promising targets for disease-modifying therapies. This includes targets which are generally believed to hold great promise with a view to therapy, targets in the first stages of preclinical research, as well as therapeutic strategies in a more advanced stage. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progressSummarizes how patients are treated today and provides a glance at future disease managementIntelligible and informative for non-specialists, medical practitioners and scientistsWritten and peer reviewed by outstanding scientists in their respective fields INDICE: 1. The multitude of therapeutic targets in neurodegenerative proteinopathies 2. Synuclein misfolding as a therapeutic target 3. Neuroinflammation as a Therapeutic Target in Neurodegenerative Diseases 4A. Stem Cells in Neurodegeneration: Mind the Gap 4B. The potential of stem cells in tackling neurodegenerative diseases 5. Preclinical models of Alzheimer's disease as tools for identification and preclinical validation of therapeutic targets: From fine-tuning strategies for validated targets to new venues for therapy 6. Disease-Modifying Therapies and Targets in Parkinson's disease 7. Disease-modifying therapies and targets in Lewy body dementia 8. Disease-Modifying Therapies and Targets in Frontotemporal dementia 9. From Huntingtin Gene to Huntington's Disease-Altering Strategies 10. Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Strategies

• ISBN: 978-0-12-805120-7
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 03/04/2017
• Nº Volúmenes: 1
• Idioma: Inglés