Molecular Diagnostics and Treatment of Pancreatic Cancer: Systems and Network Biology Approaches

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scalesCoverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas - helping researchers in pancreatic cancer drug discoverySummarizes many relevant computational and clinical references from fast-evolving literatureComprehensive glossary helps newer readers understand technical terms and specialized nomenclature INDICE: An Integrated Systems Approach to the Study of Pancreatic CancerSystems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy ResistanceProteomics of Pancreatic Cancer Stem CellsSystems and Network Guided Pancreatic Cancer DrugsPrioritizing Pancreatic Cancer Related miRNAs Using Systems PlatformPancreatic Proteome Guided Biomarker DiscoveryProteomic Analysis of Pancreatic BiopsiesRNAi Screen in Pancreatic Cancer Drug DevelopmentModeling Apoptotic Signaling in Pancreatic CancerGenetic, Epigenetic, and Proteomic Evaluation Post Laser Microdissection of Pancreatic TumorsProteomic Analysis of Gemcitabine ToxicityUnderstanding Pancreatic Cancer through Proteomics of Stellate Cells in Rat ModelsGenome Wide CpG Profiling of Intraductal Papillary Mucinous Neoplasms of the PancreasProteomic Profiling of Archival Lesions in Pancreatic CancerComputational Assessment of Benign and Potentially Malignant Pancreatic CystsPancreatic Cancer PharmacogenomicsSystems Biology on Pancreatic Splice VariantsSystems and Network for Pancreatic Cancer Drug Discovery

• ISBN: 978-0-12-408103-1
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 13/07/2014
• Nº Volúmenes: 1
• Idioma: Inglés