Muscle aging, inclusion-body myositis and myopathies

The aging of society is leading to many challenges across all areas of medicine. The problems of muscle aging have led to a rise in the incidence of less common conditions, which though not terminal are debilitating and frequently progressive, and often underdiagnosed or misdiagnosed. Written by a team of international experts, this landmark book will look at the general clinical problems associated with muscle aging before examining inclusion-body myositis and myopathies, a group of the more important diseases of muscle aging. With case vignettes to aid diagnosis to ensure correct management of an illness, here is an essential reference for professionals and students. INDICE: List of Contributors, viiPreface, xiPart 1 Muscle Aging1 Aging of the human neuromuscular system: pathological aspects, 3W. King Engel and Valerie Askanas2 Aging of the human neuromuscular system: clinical considerations, 33W. King Engel and Valerie Askanas3 Aging of the human neuromuscular system: patient vignettes, 55W. King Engel, Shalini Mahajan, and Valerie Askanas4 Mitochondrial changes in aging with particular reference to muscle, and possible clinical consequences, 81Salvatore DiMauro, Eric Schon, and Michio Hirano5 Protein degradation in aging cells and mitochondria: relevance to the neuromuscular system, 89Jenny K. Ngo and Kelvin J. A. Davies6 Human muscle protein metabolism in relation to exercise and aging: potential therapeutic applications, 97Micah J. Drummond and Blake B. RasmussenPart 2 Sporadic Inclusion-Body Myositis7 Pathogenesis of sporadic inclusion-body myositis: role of aging and muscle-fiber degeneration, and accumulation of the same proteins as in Alzheimer and Parkinson brains, 111Valerie Askanas, W. King Engel, and Anna Nogalska8 Inflammatory and autoimmune features of inclusion-body myositis, 146Marinos C. Dalakas9 Sporadic inclusion-body myositis: clinical symptoms, physical findings, anddiagnostic investigations, 159Frank L. Mastaglia10 Pathologic diagnostic criteria of sporadic inclusion-body myositis and hereditary inclusion-body myopathy muscle biopsies, 168Valerie Askanas and W. King EngelPart 3 Hereditary Inclusion-Body Myopathies11 Function and mutations of the GNE gene leading to distal myopathy with rimmed vacuoles/hereditary inclusion-body myopathy, animal models, and potential treatment, 177May Christine V. Malicdan, Satoru Noguchi, and Ichizo Nishino12 GNE myopathy (hereditary inclusion-body myopathy/distal myopathy with rimmed vacuoles): clinical features and epidemiology, 191Zohar Argov, Ichizo Nishino, and Ikuya Nonaka13 Consequences of the hereditary inclusion-body myopathy-characteristic GNE mutations on muscle proteins in vivo and in vitro, 199Aldobrando Broccolini and Massimiliano Mirabella14 Function and structure of VCP mutations leading to inclusion-body myopathy associated with Paget disease of bone and frontotemporal dementia, 206Cezary Wojcik15 Clinical spectrum of VCP myopathy, Paget disease, and frontotemporal dementia: experimental models and potential treatments, 219Virginia E. Kimonis, Eric Dec, Mallikarjun Badadani, Angele Nalbandian, Jouni Vesa, Vincent Caiozzo, Douglas Wallace, Barbara Martin, Charles Smith, and Giles D. Watts16 Drosophila and mouse models of hereditary myopathy caused by mutations in VCP/p97, 230Nisha M. Badders and J. Paul TaylorIndex, 241

• ISBN: 978-1-4443-9831-1
• Editorial: Wiley-Blackwell
• Encuadernacion: Rústica
• Páginas: 252
• Fecha Publicación: 04/04/2012
• Nº Volúmenes: 1
• Idioma: Inglés