Heat shock proteins and the brain: implications for neurodegenerative diseases and neuroprotection

With the prevalence of neurodegenerative diseases on the rise as average lifeexpectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis have been termed 'protein misfolding disorders' that are characterized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a therapeutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Written by leaders in the field of neurodegenerative diseases and neuroprotection Provides up-to-date reviews on the most recent concepts of the role of heat shock proteins in repair and protective mechanisms in the brain INDICE: From the contents Part I: Heat Shock Proteins and Neurodegenerative Diseases. Part II: Heat Shock Proteins and Neuroprotection. Part III: Extracellular Heat Shock Proteins and the Nervous System. Part IV: Aging, Control ofLife Span and Expression of Heat Shock Proteins. Index.

• ISBN: 978-1-4020-8230-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 390
• Fecha Publicación: 01/05/2008
• Nº Volúmenes: 1
• Idioma: Inglés