Liposomes in Drug Delivery: What, Where, How and When to deliver

Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/characterize/investigate/optimize liposome properties for a particular application. The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvantages, and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/technologies for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication. Focuses on key information - What, Where, How and When to deliver - needed for drug delivery researchersCovers all aspects of liposomes in drug delivery in one single volumeGuides researchers through the decision process on whether and what liposomes are most applicable to their particular interest INDICE: Part I - Basic concepts of Liposome-Assisted Drug Delivery1. Introduction to Liposome Assisted Drug Delivery2. Basic concepts of Liposome: components, structures, properties and classification3. Liposome Characterization Methodologies(Physical and Chemical Methods)4. Liposome Characterization Methodologies - Morphological Assessments by Microscopy5. Liposome Stability and Integrity6. In vivo fate of Liposomes: Biodistribution and cell membrane interactionsPart II - Mechanisms of Liposome Drug Delivery7. Liposomes in controlled drug delivery: Controlling drug release kinetics and biodistribution/pharmacokinetics8. Liposome surface modifications-Engineering techniques9. Activatable liposomes: Ultrasound-activated liposomes and lipid vesiclesPart III - Liposome Applications in drug delivery10. Liposomes for drug delivery to the brain11. Liposomes for drug delivery to cancer cells12. Liposomes as vaccine delivery systems13. Liposomes as DNA, mRNA and oligonucleotide delivery vectors14. Liposomes for drug delivery by localized routes of administration15. Liposome for drug delivery against infectious diseases16. Liposomes for drug delivery via biomaterials17. Liposomes for delivery of substances for other (non-therapeutic) applicationsPart IV -Liposome fabrication18. Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs )19. Size reduction, purification, sterilization and storage/packaging of Liposomes20. Methods for preparation of Giant liposomes: Conventional methods; Modified electro-techniques21. Microfluidic methods for liposome formation22. Supercritical fluids and other novel methods for liposome formation23. Design of experiment approaches for liposome property optimization24. Development of generic liposome products for drug deliveryPart V - Conclusions and Perspectives25. Success stories, Final remarks and directions of the field

• ISBN: 978-0-443-15491-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 696
• Fecha Publicación: 15/04/2024
• Nº Volúmenes: 1
• Idioma: Inglés