This will be the first single-volume book that addresses the entire process of discovery, development, and clinical application of therapeutic monoclonal antibodies. In this 70-chapter exhaustive reference, readers are provided with experimental data to illustrate theories and essential methodologies. The bookcovers 1) basic antibody biology; 2) antibody sources; 3) antibody engineering; 4) physiology and in vivo biology; 5) antibody production and delivery; 6) antibody therapeutic targets; 7) therapeutic monoclonal antibodies in clinicaluse and clinical trials; and 8) biogenerics/biosimilars. Monoclonal antibodies are used widely as diagnostic and research agents. Examples of their use in human therapy include: aiding in the suppression of the immune system, which occurs, for example, in kidney transplant rejections; killing or inhibiting malignant cells that proliferate in various forms of lymphoma and leukemia; angiogenesis inhibition, which is needed to treat colorectal cancer, for instance; and more recently, even aiding to prevent reclogging of coronary arteries in patients who have undergone angioplasty.
- ISBN: 978-0-470-11791-0
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 896
- Fecha Publicación: 18/09/2009
- Nº Volúmenes: 1
- Idioma: Inglés