Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology

Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology covers the major mechanisms and effects of toxic substances on the immune system, and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, and emerging and future trends. The book begins with a discussion of the systemic approach to toxicants, but also looks at current genomic tools used to assess immunotoxicity and systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data.This book provides a collaborative, multidisciplinary approach for researchers in the fields of toxicology, genetics, immunology, and others engaged in the study on the effects of toxic substances on immune responses. Offers background and progress information for clinical applications and potential immunotoxicogenomics prospectsCovers the major mechanisms currently known by which toxic substances affect the immune system and gene expressionProvides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives INDICE: 1. Immunotoxicogenomics: A systemic approach in the study of toxicants2. Immunotoxicity assessment with genomic tools3. Current systems biology methods used in Immunotoxicogenomics4. Immunogenetic reaction to ecotoxicants5. Genomic expression profiling: A potent approach in the study of immunotoxicity6. Recent developments and new opportunities of Immunotoxicogenomics7. Understanding and predicting induced immunotoxicity from gene expression8. Application of Immunotoxicogenomic data in human risk assessment process9. Immunotoxicogenomics: moving from observation to prediction.10. In-vitro high throughput approaches to assess Immunotoxicogenomics11. Microarray analysis to examine the effects of immunosuppressive compounds on changes in gene expression12. Successful use of immunotoxicogenomics as a screening tool13. Network and pathway analysis of Immunotoxicogenomics dataFuture trends in Immunotoxicogenomics

• ISBN: 978-0-443-18502-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/11/2024
• Nº Volúmenes: 1
• Idioma: Inglés