Chiral separation methods for pharmaceutical and biotechnological products

This book provides readers with an understanding of chiral separations, and offers a handy guide for selecting the best separation method, saving considerable time and cost in product development. It also discusses chiral separationsin the biotechnological and pharmaceutical industries, as well as for agriculture and food applications. Specific topics covered include high pressure liquid chromatography (HPLC), nuclear magnetic resonance (NMR), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), computational studies,and enantiomer selection. This is an essential text for analytical and separations scientists in the biotechnological, pharmaceutical, agricultural, and food industries, as well as students INDICE: 1. Overview. 2. Regulatory & Development Considerations of Chiral Compounds. 3. Basic Considerations in Method Development for Chiral Compounds.4. Separations of Chiral Compounds on Polysaccharide Columns. 5. Chiral Separations by Various Techniques. 6. Chiral Discrimination Study for Polysaccharide Based Chiral Stationary Phase. 7. Comparison of Chiral Chromatographic Columns for Pharmaceuticals. 8. Chiral Separation Screens for Pharmaceutical Analysis and Purification in an Industrial Laboratory Environment. 9. The Separationof Enantiomers by Gas Chromatography on Chiral Stationary Phases. 10. Separations of Chiral Compounds by SFC. 11. Chiral Separations by Capillary Electrophoresis. 12. High-Throughput Screening and Method-Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE. 13. Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers. 14. A Look into the Future: Chiral Analysis Using Chemical Sensor Technology. 15. Chirality of Biomolecules and Biotechnology Products.

• ISBN: 978-0-470-40691-5
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 496
• Fecha Publicación: 12/11/2010
• Nº Volúmenes: 1
• Idioma: Inglés