Since this book is geared to be used by varied groups of readers such as advanced students and instructors in the fields of biology and medicine, scientists and more importantly clinicians, it is considered important to provide briefaccounts of the basics of DNA damage, repair, mutagenesis and cancer. The purpose of this book is to present an updated detailed account of some important additional diseases of DNA repair. It has not been possible to cover all the DNA repair deficient diseases in this volume, hence diseases such as Bloom’s syndrome, Werner’s syndrome, Nijmegen breakage syndrome, ataxia telangiectasia?like disorder, RA D 50 deficiency, RIDDLE syndrome and others will be presentedin a forthcoming volume. Presents an updated detailed account of some important additional diseases of DNA repair Aimed to maintain a balance between the DNA repair diseases that have been studied exhaustively, well?defined genetic defects in DNA repair system(s) and those diseases that shows a tangential association with DNA repair defects and hence more studies are warranted Beneficial to the clinicians in treating their specialized cases INDICE: Triple?A Syndrome.- Amyotrophic Lateral Sclerosis.- Early?Onset Ataxia with Ocular Motor Apraxia and Hypoalbuminemia/Ataxia with Oculomotor Apraxia 1.- Clinical Features and Pathogenesis of Alzheimer’s Disease: Involvementof Mitochondria and Mitochondrial DNA.- Huntington’s Disease.- Clinical Features and MolecularMechanisms of Spinal and Bulbar Muscular Atrophy (SBMA).- Spinocerebellar Ataxia with Axonal Neuropathy.- Tuberous Sclerosis Complex and DNA Repair.- Hereditary Photodermatoses.- Trichothiodystrophy: Photosensitive, TTD?P, TTD, Ta y Syndrome.- Cornelia de Lange Syndrome.- Rectal Cancer and Importance of Chemoradiation in the Treatment.- Familial Cutaneous Melanoma.- Primary Immunodeficiency Syndromes.- Inherited Defects of Immunoglobulin Class Switch Recombination.- Ligase IV Syndrome.- Muir?Torre Syndrome.- Wilms’ Tumor.- Cerebro?Oculo?Fa cio?Skeletal Syndrome.- Dyskeratosis Congenita.- Retinoblastoma.- Von Hippel Lindau Syndrome.
- ISBN: 978-1-4419-6447-2
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 256
- Fecha Publicación: 29/08/2010
- Nº Volúmenes: 1
- Idioma: Inglés