Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimers Disease

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer's Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer's Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer's Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disordersExamines different classes of compounds currently being used in discovery and development stagesExplores in vitro and in vivo models with respect to their ability to translate these models to human conditionsDistills the most significant information across multiple areas of Alzheimer's disease research to provide a single, comprehensive, and balanced resource INDICE: General description of neurodegenerative disordersAlzheimer's disease diagnosisNational plan and resources to address Alzheimer's diseaseCurrent Medications for Treatment of Alzheimer's Disease:  Acetylcholine esterase inhibitors and NMDA receptor antagonistPhysicochemical properties for potential AD drugsReceptor approachesAmyloid hypothesisTau proteinsCholesterol and fat metabolismEnergy MetabolismSimple in vivo models of Neurodegeneration (C. Elegans, fruitfly, and similar models) Rodent ModelsClinical TrialsNon-pharmacologic Treatment Approaches

• ISBN: 978-0-12-802810-0
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 256
• Fecha Publicación: 01/10/2016
• Nº Volúmenes: 1
• Idioma: Inglés