As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumorsuppression. Will cover many of the recent findings in the area of senescenceand cancer, including chapters that discuss telomeres and senescence signals,the senescent phenotype, and the physiological effects of senescence, including therapeutic applications INDICE: Telomere biology and biochemistry.- Short telomere-driven senescence.- Oncogene-induced senescence.- Stress-induced senescence.- Modulation of senescence by extracellular growth factors.- The senescent phenotype and its evolution.- Chromatin structure in senescent cells.- A comparison of senescence in mouse and human cells.- Tumor suppression.- Tissue aging.- Senescence as a potential therapeutic tool.
- ISBN: 978-1-4419-1074-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 250
- Fecha Publicación: 01/12/2009
- Nº Volúmenes: 1
- Idioma: Inglés